When would I use the ALBAclone® Advanced Partial RhD Typing Kit?

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When would I use the ALBAclone® Advanced Partial RhD Typing Kit? 

The Advanced Partial RhD Typing Kit is particularly useful in those patients whose RhD type appears by standard typing techniques as D+ or Weak D+, and who demonstrate Anti-D, yet their Anti-D does not react with their own red cells. 

Is it difficult to use?

The Advanced Partial RhD Typing Kit is not hard to use.  Essentially, you run a series of anti-D tests – and record them on the profile sheet included with the package.  You then compare the reaction pattern you obtained with the patterns on the profile sheet to determine the category of partial D. 

What might be the advantages of testing with the ALBAclone® Advanced Partial RhD Typing Kit?

Testing with the Advanced Partial D test is quick.  Obtaining a pattern with the Partial D kit allows the laboratory to determine that the patient is a Partial D, and capable of building a clinically significant Anti-D.  The need to transfuse RhD negative blood is certain. Patient care is improved.  The Advanced Partial D is more cost effective than molecular sequencing, which is often necessary to determine the single nucleotide changes that distinguish Partial D types.   

How would I report the results since the kit is unlicensed?

A phrase similar to this could be reported:

The patient demonstrates Anti-D in their serum which is non-reactive with their own red cells.  When the patient’s red cells were tested with a panel of monoclonal anti-D seras, variable reactivity was noted, suggesting that the patient is missing a portion of the RhD antigen.  Persons who have an altered D epitope, or Partial D red cells, are capable of making a clinically significant alloantibody directed to that portion of the RhD antigen that they are missing.

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